Vacation home rentals in Upstate South Carolina

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Upstate South Carolina

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Vacation home in Pisgah Forest

4.99 out of 5 average rating, 67 reviews

Wake surrounded by views of the beautiful Blue Ridge Mountains in this lovely 1 bedroom vacation home.

Forget your worries in this spacious and serene space with indoor fireplace,full kitchen,laundry room,air, covered parking,large deck and outdoor fire pit/dining area. Minutes from hiking,biking,fishing,golf, 200+ waterfalls, dining, downtown Brevard, shopping,local breweries. Located between Pisgah National and DuPont State Forests. 30 minutes from Asheville airport and 20 minutes from historic Hendersonville. Brevard Music Center, Cradle of Forestry,Flat Rock Playhouse, Biltmore House nearby

Guest favorite

Vacation home in Seneca

4.91 out of 5 average rating, 35 reviews

Cozy cottage 15 mins Clemson, 7 mins lake Keowee

This efficiency apt has it all kitchen with conv microwave, fridge, coffee maker & cooktop. Surrounded by Oconee county country club golf course only 1 mile to Walmart and shopping The stars are amazing seclusion but still close to town and 30 mins to the blue ridge mountains. We are 7 mins to beautiful lake Keowee. Please note 5 people should be family as it is tight. the person booking the property must be staying on the property No construction equipment or trucks allowed on the property**

Guest favorite

Vacation home in Seneca

5.0 out of 5 average rating, 15 reviews

Pirate's Retreat - Lake Home close to Clemson

Enjoy a relaxing stay on the water. Beautiful 3 bedroom, 2 bath home with everything from a dock in deep water, 2 kayaks, new appliances and furniture ,board games, DVDs, wine refrigerator, gas grill, inflatable kayak, game room, and outdoor games for your enjoyment. The property has a great view of the lake and mountains and is only a short 15 to 20 min drive to Clemson University. Walking distance from South Cove Park featuring tennis, pickleball, basketball, and use of the boat ramp.

Guest favorite

Vacation home in Roebuck

4.87 out of 5 average rating, 54 reviews

Patriot Point B, an inviting studio apartment

This patriot themed studio apartment sleeps 5. The apartment includes a queen, pull out queen sofa bed, optional roll out full bed, a full kitchen, 1 bathroom, full laundry area, with areas for relaxing, bonfire and a gas grill. The apartment offers cozy patriotic decor including several historic homes in the area. It's charming and includes a large room with designated areas for the bed and living area, a kitchen and separate bath. We are minutes from downtown Spartanburg. Kerri & Brian

Guest favorite

Vacation home in Greenville

4.88 out of 5 average rating, 110 reviews

Dreamy City Gem Walk to Main St-Downtown & Falls

Vardry Place. Walk picturesque GVL from a prime location 1/2 block fr Main. Enjoy downtown/boutiques/art galleries/museums/tours/eateries/breweries/outdoor activities. Great for business travelers/family/friends. Our West End gem is 5 min walk to bikes/trolley @Fluor Field.10 min walk to Falls. Uber friendly too !Completely remodeled spacious historic bldg! 1300 sq.ft entire 1st floor.High ceilings, wood floors, 1 King Bed, 1 Queen bed, kitchen/living/dining/patio. FREE Parking

Guest favorite

Vacation home in Anderson

5.0 out of 5 average rating, 66 reviews

Bass 2 Splash upscale lakefront home with dock

Our immaculate 2020 built water-themed home is a luxury furnished lakefront 1.1 acre property on Lake Hartwell with a large boat dock. Our house enjoys amazing lake views and is perfect for the tournament fisherman, the boating enthusiast, golfers, families and those just needing to relax. We are down the street from Stonecreek Cove Golf Course in a countryside atmosphere and are comfortably close to the renowned Green Pond Landing, host to many national fishing tournaments.

Guest favorite

Vacation home in Highlands

5.0 out of 5 average rating, 27 reviews

Broadview A Highlands Mountain Top Retreat

Relax with the whole family while taking in the sounds of nature from atop, at Broadview. Known for its beautiful sweeping views of the breathtaking Blue Valley you’ll have a front row seat to enjoy the magic of nature as morning sunrises and evening sunsets surprise you daily. Broadview has been re-born into a chef’s dream retreat. Perfect for entertaining family and friends inside or outside on the sprawling screened porch or the open terrace overlooking Blue Valley.

Guest favorite

Vacation home in Waterloo

4.96 out of 5 average rating, 23 reviews

Too Da' Loo-Lake Adjacent Pet Friendly Retro Home!

Pet friendly, retro/nostalgic, farmhouse style lake adjacent (NOT LAKEFRONT) Clayton 2021 split bedroom floor plan 1300 sq ft mobile home, large front deck, seasonal Lake Greenwood views & creek side, 5'H + fenced yard. It's located on over an acre lot with plenty of vehicle parking on the private driveway. All of this before you reach the lake and other area attractions! Launch your boat or jet ski just one mile away at Doken Marina Great neighborhood & paved roads.

Guest favorite

Vacation home in Bryson City

4.96 out of 5 average rating, 48 reviews

Nantahala River 2BR - Bear Cave Boat Parade

Closest Nantahala River rental to the Nantahala Outdoor Center! 1.5 miles upriver. 2 BR 1 Bath. Outdoor Shower and hot water troughs. Trains daily. Boat parade floats to the NOC where there are AT hikers, mountain bikers, families. Read house rules B4 booking. WARNING: Not safe for children due to powerful water just off deck. NO WI-FI. CELL: Verizon = Excellent. T Mobile = No Coverage. ATT Some Coverage Outdoors. No Smoking. No trash service in area. Must remove.

Guest favorite

Vacation home in Hendersonville

5.0 out of 5 average rating, 49 reviews

Quiet Mountain Retreat (Belgian waffle ride 6/22)

Kick back and relax in this calm, country atmosphere close to Dupont and Pisgah forests. We're on a beautiful road for biking and walks. There are hiking trails and a creek on the property for hikes with the family and pets. For all the bikers out there, we’re on the Belgian Waffle Ride Trail for North Carolina. There are a number of restaurants in Hendersonville and Brevard (please see our guidebook for recommendations re: restaurants and activities).

Guest favorite

Vacation home in Tryon

5.0 out of 5 average rating, 72 reviews

Sandy Plains Fountain Home | King Bed | 3 MI TIEC

2 Bedroom, 1 king bed & 1 queen, 1 bath Efficiency kitchen ( we are testing an additional space that we have recently added as another bedroom as an extra bonus room ) there will be an extra 50$ a night added separately by the host for use Detached Laundry facility on property where nature surrounds you with additional outside seating & dining . Peaceful and centrally-located 3 miles from Tryon International Equestrian Center TIEC & local wineries .

Guest favorite

Vacation home in Toccoa

4.97 out of 5 average rating, 36 reviews

Mountain Views / Resort Style Pool / Wedding Venue

Cherrywood Ranch is one of a kind luxury home and wedding venue. The venue has an extra fee. With over 35 acres, a resort-style pool with a hot tub, fire pit, grill, and many other amenities for you and your family to enjoy at the foothills of the north Georgia mountains. Bring your friends and family, and enjoy the Epic Beauty of Cherrywood Ranch and its surroundings. The Frady Branch Equestrian and Bike Trail System is across the street from our property.