House vacation rentals in Pickens County
Find and book unique houses on Airbnb
Top-rated house rentals in Pickens County
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Pickens County house rentals
House rentals with a pool
Home in Easley
4.96 out of 5 average rating, 45 reviewsYour Carolina Oasis Awaits! *Pets FREE V(´ᴥ`)V
Apr 5 – 12
Home in Six Mile
4.82 out of 5 average rating, 17 reviewsClemson Getaway~Lake Keowee Dock
Aug 9 – 16
Home in Salem
4.75 out of 5 average rating, 8 reviewsKeowee Key - Lake, deck, firetable & Clemson!
Jan 29 – Feb 5
Home in Salem
5.0 out of 5 average rating, 9 reviewsNewly Updated | Lake Keowee | Pool | Amenities
Dec 23 – 30
Home in Salem
4.9 out of 5 average rating, 10 reviewsLake Keowee Home near Clemson, boating, and hiking
Sep 29 – Oct 6
Home in Salem
5.0 out of 5 average rating, 4 reviewsGolf view, lake access, 3 pools!
Nov 24 – Dec 1
Home in Salem
5.0 out of 5 average rating, 5 reviewsLake Keowee condo by marina&pool close to Clemson
Jun 2 – 9
Home in Pickens
5.0 out of 5 average rating, 10 reviewsTable Rock Retreat - Pool Home In the Mountains
Apr 11 – 18
Weekly house rentals
Home in Six Mile
4.87 out of 5 average rating, 197 reviewsHouse on Lake Keowee swim beach in cove w/ Dock
Jan 19 – 26
Home in Seneca
4.99 out of 5 average rating, 169 reviewsLakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤
Mar 20 – 27
Home in Central
4.97 out of 5 average rating, 129 reviewsClemson Carriage House | Private Guest House
Jan 13 – 20
Home in Easley
4.92 out of 5 average rating, 177 reviewsSpectacular Lakefront Retreat on the Saluda
Mar 30 – Apr 6
Home in Clemson
4.84 out of 5 average rating, 130 reviewsClemson Memorabilia house Frank Howard III’s home
Jun 21 – 28
Home in Pickens
4.96 out of 5 average rating, 84 reviewsCottage in Pickens
Jan 10 – 17
Home in Liberty
4.92 out of 5 average rating, 53 reviews12 min to Clemson | Quiet home in small town S.C.
Jul 14 – 21
Home in Easley
4.93 out of 5 average rating, 28 reviewsRespite House
Dec 16 – 23
Private house rentals
Home in Pickens
5.0 out of 5 average rating, 21 reviewsTekoa at Table Rock
Feb 17 – 24
Home in Easley
5.0 out of 5 average rating, 5 reviewsCalming Quiet Home to Recharge
Jun 1 – 8
Home in Easley
4.88 out of 5 average rating, 78 reviewsLivin' Easley-walk to downtown-close to everything
Dec 1 – 8
Home in Travelers Rest
5.0 out of 5 average rating, 42 reviewsModern Wooded Retreat
Jun 30 – Jul 7
Home in Seneca
4.98 out of 5 average rating, 42 reviewsHanover Haven 3 BR/2 Bath
Jul 10 – 17
Home in Pendleton
4.98 out of 5 average rating, 54 reviewsRaven's Ridge
Apr 25 – May 2
Home in Seneca
5.0 out of 5 average rating, 46 reviewsModern & Cozy Cottage-12 min. from Clemson Uni.
Aug 4 – 11
Home in Six Mile
5.0 out of 5 average rating, 5 reviewsLake Keowee Cottage with Beach Access
Apr 9 – 16
Destinations to explore
- Townhouse rentals United States
- Lighthouse rentals United States
- Earth house rentals United States
- House rentals United States
- Guesthouse rentals United States
- Guesthouse rentals Great Smoky Mountains
- House rentals Great Smoky Mountains
- Townhouse rentals Great Smoky Mountains
- Tiny house rentals Great Smoky Mountains
- Lakehouse rentals Great Smoky Mountains
- Lakehouse rentals Gatlinburg
- House rentals Gatlinburg
- Townhouse rentals Asheville
- Tiny house rentals Asheville
- Guesthouse rentals Asheville
- House rentals Asheville
- Lakehouse rentals South Carolina
- Beach house rentals South Carolina
- Townhouse rentals South Carolina
- House rentals South Carolina
- Guesthouse rentals South Carolina
- Tiny house rentals South Carolina
- Rentals with a patio Pickens County
- Kid-friendly rentals Pickens County
- Apartment rentals Pickens County
- Cabin rentals Pickens County
- Rentals with outdoor seating Pickens County
- Monthly Rentals Pickens County
- Condo rentals Pickens County
- Rentals with a fireplace Pickens County
- Rentals with a hot tub Pickens County
- Rentals with a kayak Pickens County
- Pet-friendly rentals Pickens County
- Rentals with lake access Pickens County
- Rentals with pools Pickens County
- Fitness-friendly rentals Pickens County
- Rentals with an EV charger Pickens County
- Rentals with a fire pit Pickens County
- Family-friendly rentals Pickens County
- Rentals with breakfast Pickens County
- Rentals with a washer and dryer Pickens County
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes