Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.93 out of 5 average rating, 316 reviewsCozy Island Cottage
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
Guesthouse in Charleston
4.99 out of 5 average rating, 263 reviewsSpacious Daniel Island Apartment
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Guesthouse in Johns Island
4.98 out of 5 average rating, 239 reviewsPrivate waterfront apt in the oaks
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 122 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Guesthouse in Charleston
4.95 out of 5 average rating, 40 reviewsGuest suite in Charleston
Guesthouse in Charleston
4.85 out of 5 average rating, 26 reviewsAdorable Studio Apartment with Patio
Guesthouse in Charleston
5.0 out of 5 average rating, 35 reviewsBeautiful Folly Beach 2 Bed Guest House
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 106 reviewsCharleston Casita near Folly Beach *Dog Friendly*
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 406 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Guesthouse in Charleston
4.99 out of 5 average rating, 206 reviewsRedesigned suite! 12min to city, pet-friendly
Guesthouse in Charleston
4.99 out of 5 average rating, 141 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Charleston
4.9 out of 5 average rating, 548 reviewsCute, Cozy, Charleston Cottage
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
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- Family travel hub Tips and inspiration
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- Kid-friendly state parks Check out these family-friendly hikes