Guesthouse vacation rentals in La Mesa
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Top-rated guesthouse rentals in La Mesa
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa guesthouse rentals
Family-friendly guest house rentals
Guesthouse in La Mesa
4.74 out of 5 average rating, 218 reviewsSan Diego/Mt. Helix Two Bedroom
Guesthouse in San Diego
4.97 out of 5 average rating, 292 reviewsPrivate Guest House with a View
Guesthouse in La Mesa
4.86 out of 5 average rating, 138 reviewsCozy Cottage
Guesthouse in San Diego
4.96 out of 5 average rating, 251 reviewsYour Kensington Bungalow
Guesthouse in Chula Vista
4.95 out of 5 average rating, 476 reviewsPrivate Casita in Great Eastlake Neighborhood
Guesthouse in San Diego
4.93 out of 5 average rating, 447 reviewsPrivate Cottage in Walkable North Park w/AC
Guesthouse in San Diego
4.99 out of 5 average rating, 364 reviews*Private Canyon Retreat: Your Own Guesthouse*
Guesthouse in San Diego
4.92 out of 5 average rating, 367 reviewsCozy 1-bdr apt in Normal Heights near Adams Ave
Guest house rentals with a patio
Guesthouse in San Diego
4.99 out of 5 average rating, 151 reviewsAdorable cottage in Talmadge
Guesthouse in La Mesa
4.99 out of 5 average rating, 167 reviewsSDCannaBnB #1 *420 *parking *dog-friendly *hot tub
Guesthouse in La Mesa
4.83 out of 5 average rating, 121 reviewsPrivate Studio with Panoramic View
Guesthouse in San Diego
4.93 out of 5 average rating, 122 reviewsModern Guest House with pool, steps to SDSU
Guesthouse in La Mesa
4.97 out of 5 average rating, 118 reviewsSan Diego Newly Built Private Guesthouse (Sleep 5)
Guesthouse in San Diego
4.85 out of 5 average rating, 124 reviewsPrivate, beautiful 1-bedroom 2 story guest house
Guesthouse in San Diego
4.99 out of 5 average rating, 108 reviewsModern Guest House with Patio, Parking, & Laundry
Guesthouse in Spring Valley
4.97 out of 5 average rating, 112 reviewsLoft Cabin-Night Cinema+Hot Soaking Tub+Views!
Guest house rentals with a washer and dryer
Guesthouse in San Diego
4.96 out of 5 average rating, 117 reviews1BR Casita in the Heart of Kensington!
Guesthouse in San Diego
4.95 out of 5 average rating, 108 reviewsRelax in a Centrally Located, Modern Guest House
Guesthouse in Lemon Grove
4.89 out of 5 average rating, 164 reviews"Glam Farmhouse dream cottage"🏠🌠
Guesthouse in El Cajon
4.99 out of 5 average rating, 152 reviewsModern mountain guest house. Incredible views
Guesthouse in El Cajon
4.96 out of 5 average rating, 131 reviewsMt Helix Studio Loft with Mountain Views
Guesthouse in San Diego
4.98 out of 5 average rating, 185 reviewsNorth Park Garden Retreat Casita
Guesthouse in San Diego
4.98 out of 5 average rating, 117 reviewsPrivate Guest House for 2 with Kitchen + Laundry
Guesthouse in San Diego
4.84 out of 5 average rating, 213 reviewsCozy Cottage
Quick stats about guesthouse rentals in La Mesa
Total rentals
60 properties
Wifi availability
60 properties include access to wifi
Rentals with dedicated workspaces
30 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Total number of reviews
3.9K reviews
Nightly prices starting at
$50 before taxes and fees
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