House vacation rentals in Florida Keys
Find and book unique houses on Airbnb
Top-rated house rentals in Florida Keys
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Florida Keys house rentals
Weekly house rentals
Home in Marathon
4.97 out of 5 average rating, 35 reviewsThe Gulf Cottage at Marathon Key
Jun 29 – Jul 6
Home in Marathon
4.97 out of 5 average rating, 36 reviewsWaterfront Private Home w/Pool-Family&Pet Friendly
Oct 6 – 13
Home in Duck Key
5.0 out of 5 average rating, 31 reviewsPrivate Pool Tropical Oasis - Centrally Located
Nov 10 – 17
Home in Marathon
5.0 out of 5 average rating, 7 reviewsMermaid's Paradise ~ Pool ~ Dock ~ Games ~ Views!
Oct 5 – 12
Home in Upper Sugarloaf Key
4.87 out of 5 average rating, 46 reviewsBungalows at Sugarloaf Beach - The Lighthouse
Oct 20 – 27
Home in Key Largo
5.0 out of 5 average rating, 14 reviewsPrivate 1 Acre House~Private Beach~Tiki Hut~Dock
Dec 14 – 21
Home in Marathon
5.0 out of 5 average rating, 9 reviewsOceanfront *PARADiSE* Amazing views, pool, dock
Feb 1 – 8
Home in Marathon
4.95 out of 5 average rating, 21 reviewsParadise in the Keys
Jun 11 – 18
Family-friendly house rentals
Home in Islamorada
4.97 out of 5 average rating, 166 reviewsFlakey's
Sep 7 – 14
Home in Key Colony Beach
4.81 out of 5 average rating, 132 reviewsWaterview from three sides, Cabana Club, 30' Docks
Dec 19 – 26
Home in Key Colony Beach
4.96 out of 5 average rating, 135 reviewsBeautiful open plan remodeled home in Key Colony
Nov 9 – 16
Home in Marathon
4.93 out of 5 average rating, 169 reviewsBeach, 70ft Dock, Entire Home, VACA-23-16
Nov 26 – Dec 3
Home in Key Colony Beach
4.9 out of 5 average rating, 133 reviewsTiki Time 2
Oct 20 – 27
Home in Cudjoe Key
4.9 out of 5 average rating, 104 reviewsSunrise Beach Escape
Oct 30 – Nov 6
Home in Marco Island
4.97 out of 5 average rating, 279 reviews⭐ Rare Waterfront Western Exposure Vacation Home
Oct 4 – 11
Home in Marco Island
4.93 out of 5 average rating, 121 reviewsMarco Paradisio - Luxury Waterfront w/ boatlift
May 18 – 25
House rentals with a pool
Home in Cudjoe Key
4.89 out of 5 average rating, 193 reviewsNewly Renovated Oceanside House with Pool
Apr 25 – May 2
Home in Key Largo
4.97 out of 5 average rating, 109 reviewsTiny Home on Waterfront | Bay Views | Deck | Pool
Feb 13 – 20
Home in Key Colony Beach
5.0 out of 5 average rating, 65 reviews“La casa azul” step 3’ to a private pool
Nov 30 – Dec 7
Home in Marathon
4.97 out of 5 average rating, 35 reviewsWaterfront Tropical Oasis in the FL Keys
Jan 4 – 11
Home in Islamorada
4.94 out of 5 average rating, 18 reviews3 Lux Ensuites Walk/Boat Island!
Mar 29 – Apr 5
Home in Marathon
4.96 out of 5 average rating, 84 reviewsAngler’s Eden
Aug 31 – Sep 7
Home in Marathon
5.0 out of 5 average rating, 32 reviews100' Dockage, Pool, Kayaks, Paddle Board, Bikes!
Apr 21 – 28
Home in Cudjoe Key
4.87 out of 5 average rating, 45 reviews*Emerald Seas*-Florida Keys Ocean Front Paradise!
Dec 1 – 8
Destinations to explore
- Miami Vacation rentals
- Miami Beach Vacation rentals
- Fort Lauderdale Vacation rentals
- Boca Raton Vacation rentals
- Key West Vacation rentals
- Naples Vacation rentals
- West Palm Beach Vacation rentals
- Varadero Vacation rentals
- Havana Vacation rentals
- Nassau Vacation rentals
- Sarasota Vacation rentals
- Anna Maria Island Vacation rentals
- House rentals Miami
- Townhouse rentals Miami
- Guesthouse rentals Miami
- Tiny house rentals Miami
- Beach house rentals Miami
- Townhouse rentals United States
- Guesthouse rentals United States
- House rentals United States
- Earth house rentals United States
- Lighthouse rentals United States
- Beach house rentals Miami Beach
- House rentals Miami Beach
- Guesthouse rentals Miami Beach
- Townhouse rentals Miami Beach
- Guesthouse rentals Florida
- Lakehouse rentals Florida
- House rentals Florida
- Townhouse rentals Florida
- Tiny house rentals Florida
- Beach house rentals Florida
- Guesthouse rentals Fort Lauderdale
- Townhouse rentals Fort Lauderdale
- House rentals Fort Lauderdale
- Beach house rentals Fort Lauderdale
- Hotel rentals Florida Keys
- Townhouse rentals Florida Keys
- Monthly Rentals Florida Keys
- Rentals with beach access Florida Keys
- Condo rentals Florida Keys
- RV rentals Florida Keys
- Pet-friendly rentals Florida Keys
- Houseboat rentals Florida Keys
- Rentals with an accessible height bed Florida Keys
- Kid-friendly rentals Florida Keys
- Tiny house rentals Florida Keys
- Rentals with an EV charger Florida Keys
- Rentals with a washer and dryer Florida Keys
- Guesthouse rentals Florida Keys
- Rentals with an accessible height toilet Florida Keys
- Smoking-friendly rentals Florida Keys
- Beach house rentals Florida Keys
- Villa rentals Florida Keys
- Apartment rentals Florida Keys
- Wheelchair accessible rentals Florida Keys
- Resort rentals Florida Keys
- Bungalow rentals Florida Keys
- Bed and breakfasts Florida Keys
- Rentals with a sauna Florida Keys
- Beach condo rentals Florida Keys
- Boat rentals Florida Keys
- Family-friendly rentals Florida Keys
- Rentals with outdoor seating Florida Keys
- Mansion rentals Florida Keys
- Rentals with a home theater Florida Keys
- Fitness-friendly rentals Florida Keys
- Rentals with lake access Florida Keys
- Rentals with pools Florida Keys
- Serviced apartment rentals Florida Keys
- Rentals with a patio Florida Keys
- Campsite rentals Florida Keys
- Rentals with a fire pit Florida Keys
- Private suite rentals Florida Keys
- Boutique hotel rentals Florida Keys
- Beachfront rentals Florida Keys
- Rentals with breakfast Florida Keys
- Cottage rentals Florida Keys
- Rentals with a hot tub Florida Keys
- Rentals with a fireplace Florida Keys
- Waterfront rentals Florida Keys
- Rentals with a kayak Florida Keys
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes