House vacation rentals in Durham County

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Top-rated house rentals in Durham County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Durham

4.88 out of 5 average rating, 200 reviews

Woodland Retreat near Duke/Downtown Durham/Eno Riv

Relax in this quaint neighborhood home tucked away in the trees. With a spacious front porch and glass doors onto deck in private backyard, this open yet cozy cottage offers the best of both worlds. Located within 5 mins of Duke Regional and Eno River State Park, close to Duke University and Hospital as well as downtown Durham. Come relax and enjoy all Durham and the RTP has to offer. This private home has a first floor bedroom and full bath as well as two more bedrooms and a full bath upstairs.

Guest favorite

Home in Durham

4.95 out of 5 average rating, 255 reviews

Perfectly Appointed @ Duke-Blue Devil Living!

Get the ultimate Duke experience at our centrally located duplex between East & West Campus. With the campus bus stop right outside your door explore Duke, Durham's museums & restaurants, and feel like a local. Our home offers the perfect mix of comfort and style, with Little Waves coffee, retro bathroom with earth safe soap products, and hotel-like bedrooms. If you need to stay close to Duke Hospital, it's just minutes away. Come live like a Blue Devil at the heart of Duke and Durham. Book now!

Guest favorite

Home in Durham

4.94 out of 5 average rating, 70 reviews

Renovated 3-bedroom home on quiet street

Newly renovated 3-bedroom, 2-bathroom house (sleeps 6) located on a quiet street and on a big 0.4 acre lot with neighbors only on one side! Comes with G-Fiber 1 Gigabit Wifi - perfect for remote work or daily use. Located between Downtown Durham, Southpoint, Research Triangle Park (RTP), and RDU Airport. Parking for multiple cars. Car highly recommended to get around and explore all that Durham has to offer! Checkin between 3-9:30pm please (after that I won’t be available to help for the night).

Guest favorite

Home in Durham

5.0 out of 5 average rating, 8 reviews

Comfy place, ideal location

Enjoy a comfortable stay in this beautiful, newly renovated home with plenty of privacy. It's also well located, close to the highways and minutes to Duke's campuses, Duke hospital, downtown and Ninth/Broad. Functional open floor plan provides plenty of space to cook, work and spend time with family and friends. Relax on the screened in back porch, grill on the back deck or sip a cup of coffee on the front porch. Each bedroom has it's own en suite bathroom and there's a half bath for guests.

Guest favorite

Home in Durham

4.97 out of 5 average rating, 35 reviews

A Home Get Away

Relax in this unique and cozy private cottage getaway just minutes from the heart of Durham. Enjoy the comforts of a newly & fully renovated adorable 2-bedroom, 1-bath house with a fully equipped kitchen that allows you to indulge in your culinary desires. Whether attending a local festival, the excitement of a college game, or simply taking in a play, no matter the reason, retreat to a cozy night stay adorned with luxurious linens & pillows, smart TVs, work surfaces, along with Wi-Fi access.

Guest favorite

Home in Durham

4.9 out of 5 average rating, 357 reviews

The Bird's Nest

This newly renovated lower level apartment is nestled in the peaceful Forest Hills neighborhood. Our space is in an ideal location to enjoy all that Durham has to offer and comes complete with everything you'll need to feel at home. Minutes from excellent restaurants, outdoor fun, and cultural entertainment. Enjoy an evening at DPAC, a Durham Bulls baseball game, an energizing game of tennis at Forest Hills park, or a relaxing stroll through Duke Gardens. All just minutes from our doorstep.

Guest favorite

Home in Bahama

4.86 out of 5 average rating, 236 reviews

Cozy & relaxing cottage on the lake *Dog Friendly*

Cozy Lake cottage on the Little River Lake. Come relax on the porch with your coffee in the mornings or take an afternoon nap on the hammock. Fish for a little in the afternoon or go down to the Little River Lake Facility and rent a canoe. It’s the perfect get away that is still close to town and wonderful restaurants. Up to two well behaved and vaccinated dogs are welcome on the property. Dog fee $75 for up to two dogs. Sorry, no cats due to allergies. Swimming is not allowed in the lake.

Superhost

Home in Downtown Durham

4.8 out of 5 average rating, 101 reviews

Historic|Twinkling Patio|Great Downtown Location!

Beautiful historic Craftsman duplex in the Cleveland Holloway neighborhood. Fully equipped kitchen, spacious living room, and original 1920 beautiful hardwoods! Complete with Laundry, plush bed, subway tiled bathtub/shower, Smart TV in living, and a gorgeous fenced in courtyard with wicker seating and twinkling cafe lights; off street parking for compact vehicles accessible through back gate. This great place to stay right near downtown will check all the boxes on your wishlist!

Guest favorite

Home in Durham

4.93 out of 5 average rating, 131 reviews

Cozy home 2mi from DPAC & Duke Hospital!

Adorable dog friendly cottage in the heart of Walltown, one of the classic neighborhoods that drive Durham's popularity. One block from Duke East Campus, three blocks from the bars and cafes of 9th street, & a short Uber or Lyft to downtown or Duke hospital. The small cottage is full of charm and character with open kitchen and living area with granite counters, tiled kitchen and bath, and back screened porch. It offers Central heat and air, dishwasher, washer/dryer.

Superhost

Home in Durham

4.87 out of 5 average rating, 141 reviews

CHARM & Convenience!! 3Br Cottage-Style Ranch

This home is located in the more DESIRABLE and 'not as congested' low crime area of Durham near Chapel Hill, on a half acre lot in the rural buffer zone! You're really convenient to Duke Hospital/Duke campus, and also just a very short drive to Chapel Hill! The backyard is BIG and completely fenced in for family games or just enjoying the birds, or your dog's exercise! Duke Forest trails and New Hope Creek are VERY nearby for a wonderful hike during your stay.

Guest favorite

Home in Durham

4.95 out of 5 average rating, 128 reviews

Cheerful 3 BR home in South Durham near everything

You'll be close to everything at this centrally-located South Durham home on a quiet cul de sac. Brand new flooring throughout the house! Dog friendly with a spacious fenced in back yard and screened in porch. The house is located one mile from the main highway and 10-20 minutes from Duke, UNC, Raleigh, RTP and more. You'll also be walking distance from a playground, dog park, grocery stores, restaurants, local coffee shop, and the Tobacco Trail.

Guest favorite

Home in Durham

4.89 out of 5 average rating, 271 reviews

Hyacinth House

Hyacinth House Newly remodeled house in the heart of a wonderful Durham neighborhood. 5 minutes to Duke University, 20 minutes to UNC Chapel Hill, 15 minutes to Research Triangle Park, 20 minutes to Raleigh-Durham Airport. Close to many shops and restaurants. Family friendly neighborhood, large fenced back yard. Screened porch. After each stay, the house is cleaned according to CDC recommendations.