Guesthouse vacation rentals in Colleton County
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Top-rated guesthouse rentals in Colleton County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Colleton County guesthouse rentals
Family-friendly guest house rentals
Guest favorite
Guesthouse in Beaufort
4.94 out of 5 average rating, 232 reviewsCozy private guest house
Guest favorite
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guest favorite
Guesthouse in Beaufort
4.94 out of 5 average rating, 398 reviewsMeridian Rd. Guest House Walk to Restaurants/Parks
Guest favorite
Guesthouse in Beaufort
4.98 out of 5 average rating, 364 reviewsThe Wren Guest House
Guest house rentals with a patio
Guesthouse in Beaufort
4.65 out of 5 average rating, 43 reviewsWaterfront! Guest House!
Guest favorite
Guesthouse in Ridgeville
4.91 out of 5 average rating, 33 reviewsCute Frog
Guest favorite
Guesthouse in Seabrook
5.0 out of 5 average rating, 47 reviewsAdorable guesthouse outside Beaufort
Guest favorite
Guesthouse in Saint George
4.97 out of 5 average rating, 59 reviewsSimmons Sweet Suite
Guest favorite
Guesthouse in Summerville
4.98 out of 5 average rating, 55 reviewsHearts & Dreams Peaceful Family Retreat w/ pool
Guest house rentals with a washer and dryer
Guesthouse in Hollywood
New place to stayCharming Country Retreat
Guesthouse in Summerville
New place to stayDetached Studio Cottage
Guest favorite
Guesthouse in Beaufort
4.88 out of 5 average rating, 113 reviewsParadise Blue, bright, airy carriage house in town
Guest favorite
Guesthouse in Beaufort
4.98 out of 5 average rating, 209 reviewsBuddy's Cottage near everything in Beaufort, SC
Guest favorite
Guesthouse in Beaufort
4.98 out of 5 average rating, 364 reviewsThe Wren Guest House
Superhost
Guesthouse in Beaufort
4.64 out of 5 average rating, 22 reviewsCozy Pets Welcome 1/1 Guest House + Shared Yard
Guest favorite
Guesthouse in Summerville
4.87 out of 5 average rating, 30 reviews1 Bed Detached Guest House, No Smokers, No Animals
Guest favorite
Guesthouse in Saint George
4.97 out of 5 average rating, 59 reviewsSimmons Sweet Suite
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