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Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost

Apartment in Puerto Ayora

4.87 out of 5 average rating, 61 reviews

Oceanview Suite: Casa Nido

Escape to our one of a kind, birds nest-inspired suite in Puerto Ayora, Galapagos. Revel in the ocean views from your private balcony, rest in the cozy hanging bed, and ascend the artistic tree staircase. This 21 sqm gem offers a fully-equipped kitchen, speedy Wi-Fi (120 mbps), a workspace, and a ventilated living space. Stroll to nearby bakeries, cafes, and eateries, or let us guide you through the best of the islands. Experience the perfect blend of minimalist elegance and rustic island charm.

Dec 10 – 17

$92 per night
Guest favorite

Apartment in Puerto Ayora

5.0 out of 5 average rating, 27 reviews

Bright and cozy 2 bedroom home away from home

Kick back and relax in this calm, stylish space. A bright and comfortable two-bedroom apartment in the heart of the Galapagos, Santa Cruz Island. Surrounded by vegetation, it is situated only four blocks from the main street, five minutes walk from the main dock, and at the entrance of Tortuga Bay. AMAZING terrace with outside dining areas. Perfect for couples or a small group of friends. It offers working spaces, a kitchen, a washing machine, all you need to have your own home in the Galapagos.

Oct 16 – 23

$131 per night
Guest favorite

Apartment in Puerto Ayora

4.97 out of 5 average rating, 131 reviews

Modern and spacious apartment in prime location

Our private, bright, spacious apartment is centrally located in Puerto Ayora 1/2 block off Darwin Avenue. The fish market, restaurants, shops, Darwin Station and main pier are just a few minutes walk away. The apartment is equipped with wifi, large kitchen with fridge, induction stovetop and microwave, and a large common area. It is good for couples, families or small groups. There are two bedrooms with A/C and sofa beds so a family group can easily be accommodated. Patio available upstairs.

Feb 15 – 22

$85 per night

Popular amenities for Santa Cruz vacation rentals

Other great vacation rentals in Santa Cruz

Guest favorite

Home in Puerto Ayora

4.97 out of 5 average rating, 35 reviews

Shangri-La Legal Rental steps to the beach

Dec 2 – 9

$384 per night
Superhost

Guesthouse in Puerto Ayora

4.88 out of 5 average rating, 40 reviews

Darwin's Suite - Ecological on the way to Tortuga Bay

Jul 15 – 22

$42 per night
Guest favorite

Townhouse in Puerto Ayora

4.97 out of 5 average rating, 39 reviews

It rents a spacious duplex.

Nov 10 – 17

$39 per night
Guest favorite

Villa in Santa Cruz

5.0 out of 5 average rating, 13 reviews

Ocean view retreat in the Galapagos highlands

Apr 15 – 22

$161 per night
Guest favorite

Home in Puerto Ayora

4.86 out of 5 average rating, 86 reviews

Casa de Pablo

Feb 7 – 14

$116 per night
Guest favorite

Townhouse in Puerto Ayora

4.9 out of 5 average rating, 78 reviews

Casa Marina Galapagos

Sep 13 – 20

$285 per night
Superhost

Tiny home in Puerto Ayora

4.79 out of 5 average rating, 33 reviews

Casita with garden and large private patio.

May 8 – 15

$61 per night
Guest favorite

Apartment in Puerto Ayora

4.94 out of 5 average rating, 54 reviews

Apartment "Raya"

Aug 8 – 15

$38 per night
Guest favorite

Guest suite in Puerto Ayora

4.98 out of 5 average rating, 49 reviews

Nice suite in Puerto Ayora, Galapagos

Jun 23 – 30

$50 per night
Guest favorite

Apartment in Puerto Ayora

4.81 out of 5 average rating, 43 reviews

Suite has access to the terrace overlooking the Bay.

Dec 17 – 24

$50 per night
Superhost

Condo in Puerto Ayora

4.87 out of 5 average rating, 39 reviews

Exclusive Condominium Galápagos & Beyond 3

Jan 30 – Feb 6

$243 per night
Superhost

Home in Puerto Ayora

4.8 out of 5 average rating, 35 reviews

Galapagos Vacation Home, Santa Cruz

Mar 20 – 27

$90 per night

Destinations to explore