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Vacation rentals in Panama

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Panama

Guests agree: these stays are highly rated for location, cleanliness, and more.

Beach House in Punta Chame!
Entire residential home · 9 guests · 5 beds · 3.5 baths

Beach House in Punta Chame!"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

El Estudio- Casa Blanca - Bajo Boquete
Entire condominium (condo) · 2 guests · 1 bed · 1 bath

El Estudio- Casa Blanca - Bajo BoqueteBright newly constructed modern industrial-designed studio in Casa Blanca, Bajo Boquete. Located on the middle level of a 3 level building. El Estudio has AMAZING views of our gorgeous valley. A short and easy walk to everything that beautiful Boquete has to offer. El Estudio has a KITCHENETTE: microwave, coffee maker, mini-fridge, single burner (induction) If you are looking for a complete kitchen, please see our other units in Bajo Boquete: El Paraíso, El Jardín or Villa Cascada.

Mot Mot Villa at Casa Mariposa
Entire guesthouse · 4 guests · 3 beds · 1 bath

Mot Mot Villa at Casa MariposaThis is one of the two villas on the property. It is within steps of the Santa Fe National park and a few kilometers from the Continental Divide, this beautiful private villa sleeps up to 4 people. A huge furnished terrace with couches, chairs and tables to eat meals at while looking at the breathtaking views ! Easy day drive to the Caribbean. Orange trees on the property for you to pick . Tons of hiking and birding. A wonderful place to stay for a really rural Panama adventure !

Vacation rentals for every style

Get the amount of space that is right for you

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Popular amenities for Panama vacation rentals

  • Kitchen
  • Wifi
  • Pool
  • Free parking on premises
  • Air conditioning

Other great vacation rentals in Panama

  1. Entire residential home
  2. Milla 3, Alto Boquete
Entire House, Large Kitchen, Outdoor Lounge
$50 per night
  1. Entire rental unit
  2. Panamá
AMAZING location with pool and rooftop A2
$59 per night
  1. Entire rental unit
  2. Panamá
Apartment with pool front the National Theater DI2
$50 per night
  1. Entire rental unit
  2. Panamá
Arias Hab Nº 6 Doble
$71 per night
  1. Entire rental unit
  2. El Chirú
Buenaventura Lux Apartment 3 BR + office
$175 per night
  1. Entire guest suite
  2. David
Casa Monèt
$35 per night
  1. Entire rental unit
  2. Playa Blanca
Apartamento con vista al mar en Playa Blanca!
$130 per night
  1. Entire townhouse
  2. Alto Boquete
Nice View House (Alto Boquete, H. Los Molinos,)
$148 per night
  1. Entire rental unit
  2. Maria Chiquita
Exclusive Apartment in Playa Escondida in Panama
$200 per night
  1. Entire guesthouse
  2. Bajo Boquete
Villa Cascada - Bajo Boquete - CLOSE TO EVERYTHING
$60 per night
  1. Entire residential home
  2. San José
Punta Barco Home near Playa Teta with Cental A/C
$130 per night
  1. Entire cabin
  2. Veraguas Province
Cosy, modern jungle retreat - miraculous sea view
$55 per night

Top-rated things to do in Panama

Unique activities hosted by local experts vetted for quality

  • Monkey Island and Panama Canal Eco tour with transfers
    Enjoy the experience of being inside the Panama Canal and knowing with all your senses the operation, history and biodiversity that surrounds it. I will pick you up at your home or accommodation in Panama City to go to the Canal Zone where we will talk about the history of the Panama Canal as we pass through different places, we will even make a stop at an observation point to see the operation of the Canal and that we can understand how it operates while we see the ships crossing. We continue by car highlighting several points of interest on the way until we reach the Soberanía National Park where we will take a boat and get into the Panama Canal. There we will pass by huge ships and experience the scale and importance of this magnificent feat of engineering. Inside the Canal we will arrive at a group of islands in a protected area in order to see as many species of animals as possible (and there are many !!), among them we will see monkeys, crocodiles, birds, iguanas, sloths and others. You will learn about the types of ships that pass through the Canal, you will identify animals and develop your vision to spot them. This is an extraordinary experience and memorable, completely outdoors and you will enjoy it a lot! Other things to note You have to remember that it is not a zoo, you will visit a natural habitat, although one of the objectives is to observe animals, it is not easy to find them, I will do everything possible and with your participation so that we can observe them but on very few occasions it is possible not to find some species.
    From Price:$64 / person
  • Colonial District Sunset Walk
    SPECIAL PRICE ($10) From Monday to Thursday ***LATE AFTERNOON *** the best time of the day for a walk at the Colonial District ***NO BLISTERING HEAT and COOL BREEZE** ***PANAMANIAN Guide*** raised and born in the neighborhood. We'll meet by late afternoon at The Plaza Herrera from where we'll start our historical walk going around the narrow streets and appreciating the mix of the architecture styles present in this colonial town, visiting several Churches and Squares , the ancient fort that protected the city. while your guide provides you interesting historical facts about the events that shaped this World Heritage Site. Also you'll have the opportunity to interact with locals along the way and visit the different shops offering souvenirs or enjoying some the local street food due the different options in the area. BOOKING: You’ve got until 1:00 pm to join this experience; EXCEPT when one or more persons have already booked, you’ve got until one hour(4:00 pm) before the tour starts to join them. TIPS AND GRATUITIES: Tipping is expected as part of Panama service culture. It’s highly appreciated and accepted, Being this said; If you consider you have received an outstanding service feel free to do so.
    From Price:$10 / person
  • Panama Canal Tour
    The Panama Canal Visitor Center in Panama City is open! We will visit the Amador Causeway, a road that connects four small islands on the Pacific, and was made with the excavated materials from the Canal. The Amador Causeway offers stunning views of Panama City skyline and the Pacific entrance of the Canal. Depending on the traffic, I will drive you through the Bridge of the Americas, one of the bridges over The Panama Canal. After crossing the bridge, we will visit a viewpoint, a special spot where you can take pictures of the bridge, the Pacific ports, and the ships. Then, we will stop at the Goethals Monument, a beautiful white Vermont marble structure built to honor George Washington Goethals for his achievements during the Panama Canal construction. Behind the Goethals Monument, you will see the Panama Canal Administration Building, a landmark of the Panamanian history built in 1914. Our next stop is at the Panama Canal Miraflores Locks Visitor Center, where you may see the ships while they pass through the Canal. You will learn about its history, operation and recent expansion. After the tour, you will be driven back to the meeting point.
    From Price:$65 / person
  • Experience the two faces of Panama City!
    Experience and Explore the two faces of Panama City: Want something different than a traditional walking tour? Victor Peretz is a passionate local taking visitors off the beaten path in El Chorillo, the forgotten side of Panama City. The poor neighborhood El Chorrillo has a bad reputation and It is widely known for social problems, crimes, violence and former gangs. It is one of the poorest areas in Panama with a population of about 20,000 people. Only 20 years ago, it was a dangerous area, often ruled by gangs. When the government and private investors started seeing the potential of this area. Many of them moved to El Chorrillo, only a stone’s throw away from Casco Viejo. Get off the beaten path with Victor and see where boxer Roberto Duran trained, learn about how the U.S. invasion of Panama affected this neighborhood, try local food and drinks, visit the park where dominoes are played, chat with the locals in their homes & get to know the people of this area, and learn about the gentrification that has taken place in the now trendy Casco Viejo historic district. The Walking Tour through El Chorrillo. Victor's idea is to show tourists the real side of Panama: the local people, their living conditions & culture. He runs the tour under the slogan: "We are more than just a famous Canal - We are People". We will experience some graffitis, cultures and traditions of Panama! Other things to note This is an experience not a tour! We will not have any standard because this is more about exploring as a local and their daily life. If you have any allergies or if you don't drink alcohol, let me know. I want to make your trip special through local food and drinks, so it's very important to know
    From Price:$75 / person
  • ⭐ Visit, understand and taste Panama ⭐
    VISIT -- following the path of colonial streets, we will walk between old buildings, churches and discover hidden places UNDERSTAND -- hear legends and stories that you won't find in the guides with some historical facts that will transport you into the past and make you understand Panama nowadays TASTE -- an experience won't be complete without trying some of Panama's local products like its handmade chocolates, drinking good coffee and sipping famous Panamanian rum... you will try the best of Panama! With a modern twist, I will also introduce the way of life, customs and key elements that represent the country. *If you would like to hear the same story but you just prefer the walking part of the experience without trying Panama´s local products, I also have that option for you: Other things to note: *During our stop in a coffee shop, Geisha coffee is not included. Group size is limited to 6 people.
    From Price:$49 / person