Lady's Island vacation rentals

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Top-rated vacation rentals in Lady's Island

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite

Guest suite in Beaufort

4.96 out of 5 average rating, 505 reviews

Shady Rest #1 near historic downtown Beaufort

Nestled among oaks, this secure, private suite is attached to our home with a separate entrance. We're close to great views, restaurants and shopping, family-friendly activities, nightlife, and the beach. You’ll love our place because of the coziness, the views, and especially the location. It's about a mile from downtown Beaufort, adjacent to the Spanish Moss Biking and Hiking Trail, 6 miles from Parris Island MCRD, convenient to Hilton Head Island, and halfway between Charleston and Savannah.

Sep 21 – 28

$110 per night
Guest favorite

Guesthouse in Beaufort

4.96 out of 5 average rating, 206 reviews

Sunset River House

Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!

Jan 19 – 26

$94 per night
Guest favorite

Cottage in Beaufort

4.95 out of 5 average rating, 205 reviews

Cara May Cottage

We love the laidback neighborhood, charming historic architecture, and the 5-block walk to the breezy waterfront along Bay Street. The cozy cottage is one bedroom, one bath, and a lovely living space on a postage stamp lot. The built-in breakfast nook is our favorite spot. Other features are the chic furnishings, 11’ ceilings, tall casement windows, and little front porch. Off-street private parking for one car and smart tv/wifi. The 400 SF cottage is named after the architect's daughter.

Dec 16 – 23

$140 per night

Popular amenities for Lady's Island vacation rentals

Other great vacation rentals in Lady's Island

Guest favorite

Guesthouse in Beaufort

4.94 out of 5 average rating, 227 reviews

Cozy private guest house

May 8 – 15

$90 per night
Guest favorite

Cottage in Beaufort

4.97 out of 5 average rating, 123 reviews

Peaceful River Retreat Near Historic District

Oct 9 – 16

$233 per night
Guest favorite

Cottage in Beaufort

4.97 out of 5 average rating, 219 reviews

Lovely Cottage in Beaufort w/ State Park Beach Pas

Sep 21 – 28

$210 per night
Guest favorite

Cottage in Saint Helena Island

4.99 out of 5 average rating, 196 reviews

Harbor River Cottage

Mar 4 – 11

$149 per night
Guest favorite

Home in Beaufort

4.99 out of 5 average rating, 291 reviews

Relaxing Retreat in Beautiful Beaufort

Aug 14 – 21

$130 per night
Guest favorite

Condo in Beaufort

4.96 out of 5 average rating, 179 reviews

Waterfront Condo

Dec 29 – Jan 5

$108 per night
Guest favorite

Home in Beaufort

4.98 out of 5 average rating, 118 reviews

Restored 1889 Historic Cottage

Jan 2 – 9

$185 per night
Guest favorite

Bungalow in Port Royal

4.87 out of 5 average rating, 126 reviews

CHEERFUL 2 BEDROOM BUNGALOW W/ PARKING ON PREMISE

Jan 2 – 9

$124 per night
Guest favorite

Home in Beaufort

4.84 out of 5 average rating, 127 reviews

Romantic Cottage for 2 - 10 min walk to downtown

Nov 4 – 11

$125 per night
Guest favorite

Cottage in Beaufort

4.98 out of 5 average rating, 155 reviews

Private Island Cottage

Apr 19 – 26

$225 per night
Guest favorite

Home in Beaufort

4.85 out of 5 average rating, 123 reviews

Charming Cottage close to Downtown

Aug 5 – 12

$125 per night
Guest favorite

Apartment in Beaufort

5.0 out of 5 average rating, 161 reviews

Sailboats and Sunsets at Lady's Island Marina

Oct 23 – 30

$157 per night

Other great vacation rentals in Lady's Island

Guest favorite

Home in Beaufort

5.0 out of 5 average rating, 108 reviews

Southern Living in Historic Downtown Beaufort.

Nov 4 – 11

$204 per night
Guest favorite

Cottage in Beaufort

5.0 out of 5 average rating, 32 reviews

Private cottage in the pines

Mar 17 – 24

$112 per night
Guest favorite

Tiny home in Beaufort

4.92 out of 5 average rating, 65 reviews

Cheerful tiny close to Parris Island & downtown

Nov 1 – 8

$91 per night
Guest favorite

Home in Beaufort

4.97 out of 5 average rating, 39 reviews

Beautiful Water Views, Dock, Yard, Private, Quiet

Aug 17 – 24

$281 per night
Guest favorite

Home in Beaufort

4.9 out of 5 average rating, 90 reviews

Veteran Owned - Less than 1 mile to Parris Island.

Jun 17 – 24

$88 per night
Guest favorite

Apartment in Beaufort

4.98 out of 5 average rating, 59 reviews

The Bird's Nest

Jul 18 – 25

$115 per night
Superhost

Home in Beaufort

4.83 out of 5 average rating, 42 reviews

On Golf Course. Quality 4 Four. Pets Yes!

Nov 6 – 13

$90 per night
Guest favorite

Home in Beaufort

5.0 out of 5 average rating, 66 reviews

Location & Charm-Close to Bay, Parris Island/MCAS

Feb 23 – Mar 2

$131 per night
Guest favorite

Home in Beaufort

4.92 out of 5 average rating, 84 reviews

Sleeps 6/Pets/2 Queens/pullout couch/Beaufort/SC

Dec 6 – 13

$120 per night
Guest favorite

Home in Beaufort

4.96 out of 5 average rating, 71 reviews

Flamingo Cove - April Availability! Only $199/nt!*

Nov 18 – 25

$216 per night
Guest favorite

Guesthouse in Beaufort

5.0 out of 5 average rating, 54 reviews

Low-country Carriage House

Jul 1 – 8

$131 per night
Guest favorite

Guesthouse in Seabrook

5.0 out of 5 average rating, 42 reviews

Adorable guesthouse outside Beaufort

Apr 15 – 22

$88 per night

Destinations to explore