Vacation rentals in Alexander County

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Top-rated vacation rentals in Alexander County

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 346 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Jan 16 – 23

$83 per night
Guest favorite

Guest suite in Cape Girardeau

4.96 out of 5 average rating, 108 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Sep 4 – 11

$69 per night
Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 116 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Feb 4 – 11

$210 per night

Popular amenities for Alexander County vacation rentals

Other great vacation rentals in Alexander County

Guest favorite

Home in Jackson

4.92 out of 5 average rating, 263 reviews

The Rusty Owl-A Charming Victorian Dwelling

May 25 – Jun 1

$106 per night
Guest favorite

Home in Clinton

4.99 out of 5 average rating, 138 reviews

The Peery House at Springhill Farms

Aug 17 – 24

$127 per night
Superhost

Home in New Grand Chain

4.9 out of 5 average rating, 102 reviews

Cozy and charming modern vintage style home

Nov 12 – 19

$96 per night
Guest favorite

Cabin in Alto Pass

5.0 out of 5 average rating, 109 reviews

Bald Knob Cabin

Aug 10 – 17

$99 per night
Guest favorite

Apartment in Dongola

4.91 out of 5 average rating, 101 reviews

Earnhart Carriage House

Jun 7 – 12

$116 per night
Guest favorite

Home in Dongola

4.97 out of 5 average rating, 116 reviews

Spacious Home in Country Setting

Jun 12 – 19

$118 per night
Superhost

Home in Olive Branch

4.84 out of 5 average rating, 79 reviews

Horseshoe Lake Escape

Jul 14 – 21

$109 per night
Guest favorite

Treehouse in Cape Girardeau

4.98 out of 5 average rating, 53 reviews

Twisted Sassafras Treehouse

Nov 13 – 20

$213 per night
Guest favorite

Home in Cairo

4.88 out of 5 average rating, 26 reviews

Traditional Family Home

May 27 – Jun 3

$118 per night
Guest favorite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 60 reviews

Private Downtown Apartment

Jun 14 – 21

$116 per night
Guest favorite

Barn in Cape Girardeau

4.95 out of 5 average rating, 100 reviews

Under the Stars - Farmhouse

Sep 2 – 9

$187 per night
Guest favorite

Home in Cape Girardeau

4.94 out of 5 average rating, 66 reviews

House Of Clubs- 2 Bed 1.5 Bath

Dec 1 – 8

$126 per night

Destinations to explore